Astragaloside VI
Astragaloside VI
CAS: 84687-45-6
Molecular Formula: C47H78O19
Astragaloside VI - Names and Identifiers
Astragaloside VI - Physico-chemical Properties
| Molecular Formula | C47H78O19 |
| Molar Mass | 947.11 |
| Solubility | 10 mM in DMSO |
| Storage Condition | 2-8℃ |
| MDL | MFCD17214426 |
| In vitro study | Pretreatment with Astragaloside VI (AS-VI) at 1 μM increases EGFR activation in HaCaT cells. Astragaloside VI, a major intestinal metabolite of astragalosides, exerts the strongest EGFR activation. In HaCaT cells, the positive control, EGF expectedly results in 1.5±0.03-fold increase in cell proliferation, compared to the control. Astragaloside VI at the indicated concentrations also significantly promots cell proliferation in both HaCaT and HDF cells. Astragaloside VI promotes neural stem cell proliferation and enhances neurological function recovery in transient cerebral ischemic injury via activating EGFR/MAPK signaling cascades. |
| In vivo study | Astragaloside VI improves wound healing, compared to the control. In the simple noninfected wound model, wound healing in mice is accelerated by Astragaloside VI, where in the time required for wound closure is shortened by approximately 2-4 days, compared to that in the control group. Topical treatment with Astragaloside VI reduces the volume of pus produced, compared to the control group. Astragaloside VI treated wounds show an accelerated rate of healing, compared to the control and vaseline groups. By day 22, the Astragaloside VI -treated wounds fully close, whereas the blank and vaseline-treated wounds do not fully close until day 26. Angiogenesis is a crucial step in the formation of granulation tissue and wound healing. Astragaloside VI increases blood vessel formation in both the non-infected and infected wound models. Astragaloside VI could effectively activate EGFR/MAPK signaling cascades, promote NSCs proliferation and neurogenesis in transient cerebral ischemic brains, and improve the repair of neurological functions in post-ischemic stroke rats. |
Astragaloside VI - Reference
| Reference Show more | 1. Li Yangyang, Zhang Yiming, Wei kongxi, Zhou Ting, He Jinpeng, Ding Nan, Zhou Gucheng, Shi tongfan, Ke Yicheng, cow fan, Liu Yongqi, Zhang Liying. Comparative study on the protective effects of different effective components of astragalus on DNA damage of BMSCs induced by ionizing radiation [J]. China Pharmacy, 2020,31(24):2987-2992. 2. Yuping Zhang, Shuyun Shi, Junfang Guo, Qingping You, Deshan Feng, on-line surface plasmon resonance-high performance liquid chromatography |
Astragaloside VI - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.056 ml | 5.279 ml | 10.558 ml |
| 5 mM | 0.211 ml | 1.056 ml | 2.112 ml |
| 10 mM | 0.106 ml | 0.528 ml | 1.056 ml |
| 5 mM | 0.021 ml | 0.106 ml | 0.211 ml |
Last Update：2024-01-02 23:10:35
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